Active Ingredients: Hydroxyzine
In one embodiment, the crystalline compartment is formulated as an immediate release compartment. In another embodiment, the crystalline compartment is formulated as a delayed release compartment e.
Optionally, the solid dosage compartment is a delayed release compartment comprising a gastroretentive compartment. Gastroretentive compartments can comprise, for example, a water-swellable polymer that swells upon imbibition of water to a size that is large enough to promote retention of the dosage form in the stomach, and provides controlled delivery of the cannabinoid e.
Optionally, the solid dosage compartment is combined with another compartment in a multi-phase dosage form.
For example, the solid dosage compartment can be provided as a delayed release compartment and combined with a liquid dosage compartment formulated for immediate release.
While any delayed release compartment is useful in the present invention, one embodiment provides a dosage compartment, wherein the compartment comprises a delayed release coating e.
For example, one or more pulsatile release coatings can be provided to deliver a burst of cannabinoid release at one or more predetermined time intervals e. For example, an otherwise immediate release compartment e. Additionally or alternatively, a delayed release compartment of the invention e.
For example, a discontinuous delayed release coating is optionally useful when one compartment e. Any release modifying coating e. Examples of such are well known in the art.
Optionally, the delayed release coating is applied in the form of an organic or aqueous solution or dispersion. Optionally, the delayed release coating comprises a plasticizer, or other excipient, such as optional excipients taught herein.
Optionally, the delayed release e.
Optionally, the delayed release coating is a water swellable sustained release coating. Optionally, the delayed release coating is low permeability coating or a high permeability coating, such as those described herein.
Optionally, the delayed release coating is a low melting point hydrophobic material e. After homogenization to generate submicron droplets, the organic solvent is evaporated under vacuum to form a pseudolatex. This product is prepared by incorporating plasticizer into the dispersion during the manufacturing process.
A hot melt of a polymer, plasticizer dibutyl sebacate, and stabilizer oleic acid is prepared as a homogeneous mixture, which is then diluted with an alkaline solution to obtain an aqueous dispersion which can be applied directly onto substrates.
Examples of useful acrylic polymers include acrylic acid and methacrylic acid copolymers, methyl methacrylate copolymers, ethoxyethyl methacrylates, cynaoethyl methacrylate, poly acrylic acid, poly methacrylic acid, methacrylic acid alkylamide copolymer, poly methyl methacrylate, polymethacrylate, poly methyl methacrylate copolymer, polyacrylamide, aminoalkyl methacrylate copolymer, poly methacrylic acid anhydride, and glycidyl methacrylate copolymers.
Optionally, a delayed release acrylic polymer is comprised of one or more ammonio methacrylate copolymers. Ammonio methacrylate copolymers are well known in the art, and are described, for example, as fully polymerized copolymers of acrylic and methacrylic acid esters with a low content of quaternary ammonium groups.
In order to tailor a dissolution profile, one may, for example, incorporate two or more ammonio methacrylate copolymers having differing physical properties, such as different molar ratios of the quaternary ammonium groups to the neutral meth acrylic esters.
In one embodiment, the delayed release coating is pH dependent.In general, sleep apnea is defined repetitive reduction in breathing hypopnea, cessation at the nose and mouth during sleep.
The global death toll stands at 45, Arabia, where 65 of the known 80 have been outbreaks in hospitals, in particular.