Active Ingredients: Ciprofloxacin
If this occurs, patients should contact their physician assoon as possible.
Drug Interactions: In a pharmacokinetic study, systemic exposure of tizanidine 4 mg single dose wassignificantly increased C max 7-fold, AUC 10-fold when the drug was given concomitantly withciprofloxacin 500 mg bid for 3 days.
The hypotensive and sedative effects of tizanidine were alsopotentiated.
This mayresult in increased risk of theophylline-related adverse reactions. If concomitantuse cannot be avoided, serum levels of theophylline should be monitored and dosage adjustments madeas appropriate.
Some quinolones, including ciprofloxacin, have also been shown to interfere with the metabolism ofcaffeine.
Histamine H 2 -receptor antagonists appear to have no significant effect on the bioavailability ofciprofloxacin. Altered serum levels of phenytoin increased and decreased have been reported in patients receivingconcomitant ciprofloxacin.
Some quinolones, including ciprofloxacin, have been associated with transient elevations in serumcreatinine in patients receiving cyclosporine concomitantly.
Quinolones, including ciprofloxacin, have been reported to enhance the effects of the oral anticoagulantwarfarin or its derivatives. Probenecid interferes with renal tubular secretion of ciprofloxacin and produces an increase in the levelof ciprofloxacin in the serum.
This should be considered if patients are receiving both drugsconcomitantly. This might increase therisk of methotrexate associated toxic reactions.
Therefore, patients under methotrexate therapy shouldbe carefully monitored when concomitant ciprofloxacin therapy is indicated. Metoclopramide significantly accelerates the absorption of oral ciprofloxacin resulting in shorter timeto reach maximum plasma concentrations.
No significant effect was observed on the bioavailability ofciprofloxacin. Non-steroidal anti-inflammatory drugs but not acetyl salicylic acid in combination of very high dosesof quinolones have been shown to provoke convulsions in pre-clinical studies.
Results from photo co-carcinogenicity testing indicate that ciprofloxacin does not reduce the time toappearance of UV-induced skin tumors as compared to vehicle control.
The times to development of skin tumors ranged from 16-32 weeks in micetreated concomitantly with UVA and other quinolones.
The clinical significance ofthese findings to humans is unknown.
Pregnancy: Teratogenic Effects. Pregnancy Category C: There are no adequate and well-controlledstudies in pregnant women.
The reported rates of major congenital malformations were 2. Rates ofspontaneous abortions, prematurity and low birth weight did not differ between the groups and therewere no clinically significant musculoskeletal dysfunctions up to one year of age in the ciprofloxacinexposed children.
Themalformation rates among live-born babies exposed to ciprofloxacin and to fluoroquinolones overallwere both within background incidence ranges.
No specific patterns of congenital abnormalities werefound.Cipro basics 250 mg nebenwirkungen medicament campsite had their hemoglobin A 1 c measured in the past 30 days, ciprofloxacin 500 mg tinidazole 600 mg this could be done to provide a better indication of glucose control Was Ist Eine Viagra Pille.
The study did not reveal any clear adverse reactions due to in utero exposure to ciprofloxacin. No differences in the rates of prematurity, spontaneous abortions, or birth weight were seen in womenexposed to ciprofloxacin during pregnancy.
The amount of ciprofloxacin absorbed bythe nursing infant is unknown. Because of the potential for serious adverse reactions in infants nursingfrom mothers taking ciprofloxacin, a decision should be made whether to discontinue nursing or todiscontinue the drug, taking into account the importance of the drug to the mother.