Active Ingredients: Doxycycline
The samples were allowed to diffuse for 2 h at room temperature, and were then incubated.
In vivo antimicrobial activity study. Eighteen male Wistar rats Rattus norvegicus of average weight, 180—210 g, were selected and grouped.
These eighteen animals were assigned into three groups six rats per group, with group 1 including healthy animals sham group, group 2 including periodontitis-induced animals negative control, and group 3 including treated animals.
Experimental periodontitis was induced in them by using the procedure described previously 6 and adopted by Xu et al.
The ligatures were tightly applied and all loose ligatures were replaced. When the disease developed, the group 3 animals were treated with the gingiva disc. In a prospective, randomized, controlled study performed by Hsu et al conducted at the Kaohsiung Veterans General Hospital in Taiwan, concomitant therapy was shown to be superior to triple therapy for H.
Similarly, Liu et al showed that both sequential therapy and modified bismuth-containing quadruple therapy were highly effective in Hong Kong Chinese patients.
Therefore, further research on clarithromycin resistance in patients worldwide is essential to ensure for the development of adequate treatments because treatments using this antibiotic have been proven to be effective in some regions of the world.
Further validation studies of different treatment method in addition to resistance studies are essential for providing clinicians with a greater range of options for the eradication of H.
Footnotes Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. Anti-Helicobacter pylori activity of plant extracts traditionally used for the treatment of gastrointestinal disorders.
Braz J Microbiol. Bismuth, moxifloxacin, tetracycline, lansoprazole quadruple first line therapy for eradication of H.
Clin Res Hepatol Gastroenterol. Diagnosis and treatment of Helicobacter pylori infection.
Dan Med Bull. Tytgat GN. Etiopathogenetic principles and peptic ulcer disease classification. Dig Dis. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol.
Christopher J. Smith, Harlan Sayles, Ted R. Mikuls, Kaleb Michaud.
Minocycline and doxycycline therapy in community patients with rheumatoid arthritis: Prescribing patterns, patient-level determinants of use and patient-reported side effects.