Active Ingredients: Doxycycline
The nonantibiotic anti-inflammatory effects of tetracyclines are under investigation for the treatment of multiple diseases.
Their efficacy has already been reported in rheumatoid arthritis, corneal inflammation, gingivitis, osteoarthritic cartilage, allergen-induced inflammation, and a lot of other conditions like cardiovascular, neurological, and skin disorders.
The wide spectrum of anti-inflammatory effects ascribed to tetracyclines is probably due to their ability to interfere with the synthesis or activity of several mediators of inflammation.
Furthermore, tetracyclines also scavenge reactive oxygen species and thereby prevent or reduce pathological tissue destruction. Another important effect, significantly contributing to the overall immune-regulatory activity of tetracyclines, is the interference with cytokine production from neutrophils and macrophages during inflammatory conditions.
The lowest dose of doxycycline available in New Zealand is 50 mg. For how long are tetracyclines taken?
Infections are treated for 7 to 28 days, depending on the condition being treated. Inflammatory disorders take several weeks or months to respond to tetracyclines such as doxycycline. This disease progresses rapidly into severe illness requiring hospitalization, or even death.
Rickettsia can cause damage to the blood vessels leading to organ failure, amputation of extremities from lack of blood flow, and neurological deficits such as hearing loss, paralysis, and encephalopathy.
It also increased plasma GSH levels.
Doxycycline did not improve antibacterial effect of ceftriaxone in combination, suggesting that the protective effect of doxycycline was due to its immunomodulatory activity.
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