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Criteria Inclusion Criteria: 1. During the first clinical episode, the goal of systemic antiviral drug therapy is to control the signs and symptoms of genital herpes.
Daily suppressive therapy is recommended for use in patients who have six or more recurrences per year. Three antiviral medications have been proved in randomized trials to provide clinical benefit in patients with genital herpes: acyclovir, valacyclovir and famciclovir.
Clinical experience with systemic acyclovir in the treatment of genital herpes has been substantial. Topical therapy is less effective than systemic therapy, and its use is not recommended. Two newer antiviral agents are valacyclovir and famciclovir.
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